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Human IRAG1 activation kit by CRISPRa

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SKU
GA107046
MRVI1 CRISPRa kit - CRISPR gene activation of human murine retrovirus integration site 1 homolog
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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RC220170 MRVI1 (Myc-DDK-tagged)-Human murine retrovirus integration site 1 homolog (MRVI1), transcript variant 1
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Other products for "IRAG1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol IRAG1
Locus ID 10335
Components

GA107046G1, IRAG1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA107046G2, IRAG1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA107046G3, IRAG1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001098579, NM_001100163, NM_001100167, NM_001206880, NM_001206881, NM_006069, NM_130385
UniProt ID Q9Y6F6
Synonyms IRAG; JAW1L
Summary This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. provided by RefSeq, May 2011
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Documents
Resources
Other Versions
SKU Description Size Price
KN415536 MRVI1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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