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Human Sprouty 2 (SPRY2) activation kit by CRISPRa

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SKU
GA106981
SPRY2 CRISPRa kit - CRISPR gene activation of human sprouty RTK signaling antagonist 2
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC204864 SPRY2 (Myc-DDK-tagged)-Human sprouty homolog 2 (Drosophila) (SPRY2)
10 ug
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Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol SPRY2
Locus ID 10253
Components

GA106981G1, Sprouty 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA106981G2, Sprouty 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA106981G3, Sprouty 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001318536, NM_001318537, NM_001318538, NM_005842
UniProt ID O43597
Synonyms hSPRY2; IGAN3
Summary This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN404864 SPRY2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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