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Human MELK activation kit by CRISPRa

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SKU
GA106629
MELK CRISPRa kit - CRISPR gene activation of human maternal embryonic leucine zipper kinase
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA302675 Goat Polyclonal Antibody against MELK
100 ug
$555.00
RC204245 MELK (Myc-DDK-tagged)-Human maternal embryonic leucine zipper kinase (MELK)
10 ug
$909.00

Other products for "MELK"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol MELK
Locus ID 9833
Components

GA106629G1, MELK gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA106629G2, MELK gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA106629G3, MELK gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001256685, NM_001256687, NM_001256688, NM_001256689, NM_001256690, NM_001256691, NM_001256692, NM_001256693, NM_014791, NR_046337
UniProt ID Q14680
Synonyms HPK38
Summary Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN404245 MELK - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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