Human Semaphorin 3E (SEMA3E) activation kit by CRISPRa

SKU GA106531

SEMA3E CRISPRa kit - CRISPR gene activation of human semaphorin 3E

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: SEMA3E
• Locus ID: 9723
• Components:

  GA106531G1, Semaphorin 3E gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106531G2, Semaphorin 3E gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106531G3, Semaphorin 3E gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001178129, NM_012431
• UniProt ID: O15041
• Synonyms: coll-5; M-SEMAH; M-SemaK; SEMAH
• Summary: Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]