Human KIAA0100 activation kit by CRISPRa

SKU GA106514

KIAA0100 CRISPRa kit - CRISPR gene activation of human KIAA0100

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: KIAA0100
• Locus ID: 9703
• Components:

  GA106514G1, KIAA0100 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106514G2, KIAA0100 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106514G3, KIAA0100 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001321560, NM_001321561, NM_014680, NM_001363827, NM_001363828, NM_001363829, NM_001363826
• UniProt ID: Q14667
• Synonyms: BCOX; BCOX1; CT101; FMP27
• Summary: This gene was initially characterized in human as having high expression levels in breast carcinomas and breast cancer cell lines. This gene also has increased expression in prostrate cancer cells relative to normal prostrate tissues. Expression of this gene is negatively regulated by direct binding of the microRNA miR-195 to its 3' UTR. miR-195 has been shown to modulate the invasiveness of prostrate cancer cells and xenograft metastases by downgrading expression of this gene. In mouse, the protein encoded by this gene was identified as an antigen on acute monocytic leukemia cells. In human, alternative splicing results in multiple transcript variants encoding distinct isoforms; some of these isoforms are predicted to contain an RNA pol II promoter FMP27 protein domain and a Golgi-body-localization APT1 domain. [provided by RefSeq, Apr 2017]