Human RIN1 activation kit by CRISPRa

SKU GA106434

RIN1 CRISPRa kit - CRISPR gene activation of human Ras and Rab interactor 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: RIN1
• Locus ID: 9610
• Components:

  GA106434G1, RIN1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106434G2, RIN1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106434G3, RIN1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_004292, NM_001363560, NM_001363559
• UniProt ID: Q13671
• Summary: Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.[UniProtKB/Swiss-Prot Function]