Human RNF14 activation kit by CRISPRa

SKU GA106430

RNF14 CRISPRa kit - CRISPR gene activation of human ring finger protein 14

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: RNF14
• Locus ID: 9604
• Components:

  GA106430G1, RNF14 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106430G2, RNF14 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106430G3, RNF14 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001201365, NM_004290, NM_183398, NM_183399, NM_183400, NM_183401
• UniProt ID: Q9UBS8
• Synonyms: ARA54; HFB30; HRIHFB2038; TRIAD2
• Summary: The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]