Human NR1D1 activation kit by CRISPRa

SKU GA106408

NR1D1 CRISPRa kit - CRISPR gene activation of human nuclear receptor subfamily 1 group D member 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: NR1D1
• Locus ID: 9572
• Components:

  GA106408G1, NR1D1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106408G2, NR1D1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106408G3, NR1D1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_021724
• UniProt ID: P20393
• Synonyms: ear-1; EAR1; hRev; THRA1; THRAL
• Summary: This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013]