Human PLAA activation kit by CRISPRa

SKU GA106253

PLAA CRISPRa kit - CRISPR gene activation of human phospholipase A2 activating protein

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PLAA
• Locus ID: 9373
• Components:

  GA106253G1, PLAA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106253G2, PLAA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106253G3, PLAA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001031689, NM_004253, NM_001321546
• UniProt ID: Q9Y263
• Synonyms: DOA1; PLA2P; PLAP
• Summary: Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986).[UniProtKB/Swiss-Prot Function]