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Human GPR37L1 activation kit by CRISPRa

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SKU
GA106191
GPR37L1 CRISPRa kit - CRISPR gene activation of human G protein-coupled receptor 37 like 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA314886 Rabbit polyclonal anti-ETBR2 antibody
100 ul
$380.00
RC208132 GPR37L1 (Myc-DDK-tagged)-Human G protein-coupled receptor 37 like 1 (GPR37L1)
10 ug
$686.00

Other products for "GPR37L1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol GPR37L1
Locus ID 9283
Components

GA106191G1, GPR37L1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA106191G2, GPR37L1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA106191G3, GPR37L1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_004767
UniProt ID O60883
Synonyms ET(B)R-LP-2; ETBR-LP-2
Summary G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594). However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN408132 GPR37L1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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