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Human AIF (AIFM1) activation kit by CRISPRa

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SKU
GA106084
AIFM1 CRISPRa kit - CRISPR gene activation of human apoptosis inducing factor mitochondria associated 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA811161 AIFM1 mouse monoclonal antibody,clone OTI4E6 100 ul
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RC224064 AIFM1 (Myc-DDK-tagged)-Human apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), nuclear gene encoding mitochondrial protein, transcript variant 1
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Other products for "AIFM1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol AIFM1
Locus ID 9131
Components

GA106084G1, AIF gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA106084G2, AIF gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA106084G3, AIF gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001130846, NM_001130847, NM_004208, NM_145812, NM_145813, NR_132647
UniProt ID O95831
Synonyms AIF; CMT2D; CMTX4; COWCK; COXPD6; NADMR; NAMSD; PDCD8
Summary This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and cognitive disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. provided by RefSeq, Aug 2015
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Documents
Resources
Other Versions
SKU Description Size Price
KN410668 AIFM1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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