Human SMC3 activation kit by CRISPRa

SKU GA106079

SMC3 CRISPRa kit - CRISPR gene activation of human structural maintenance of chromosomes 3

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: SMC3
• Locus ID: 9126
• Components:

  GA106079G1, SMC3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106079G2, SMC3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106079G3, SMC3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_005445
• UniProt ID: Q9UQE7
• Synonyms: BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1
• Summary: This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]