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Human LATS1 activation kit by CRISPRa

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SKU
GA106068
LATS1 CRISPRa kit - CRISPR gene activation of human large tumor suppressor kinase 1
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC223650 LATS1 (Myc-DDK-tagged)-Human LATS, large tumor suppressor, homolog 1 (Drosophila) (LATS1)
10 ug
$1,475.00

Other products for "LATS1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol LATS1
Locus ID 9113
Components

GA106068G1, LATS1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA106068G2, LATS1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA106068G3, LATS1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001270519, NM_004690, NR_073033, NM_001350339, NM_001350340, NM_001350392
UniProt ID O95835
Synonyms WARTS; wts
Summary The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. provided by RefSeq, Apr 2017
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Documents
Resources
Other Versions
SKU Description Size Price
KN423650 LATS1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

file-alt Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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