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Human PSTPIP1 activation kit by CRISPRa

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SKU
GA106018
PSTPIP1 CRISPRa kit - CRISPR gene activation of human proline-serine-threonine phosphatase interacting protein 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA370903 PSTPIP1 rabbit polyclonal antibody
100 ul
$310.00
RC203788 PSTPIP1 (Myc-DDK-tagged)-Human proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1)
10 ug
$457.00

Other products for "PSTPIP1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol PSTPIP1
Locus ID 9051
Components

GA106018G1, PSTPIP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA106018G2, PSTPIP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA106018G3, PSTPIP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001321135, NM_001321136, NM_001321137, NM_003978, NR_135552
UniProt ID O43586
Synonyms CD2BP1; CD2BP1L; CD2BP1S; H-PIP; PAPAS; PSTPIP
Summary This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response. provided by RefSeq, Mar 2016
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Documents
Resources
Other Versions
SKU Description Size Price
KN403788 PSTPIP1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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