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Human BRSK2 activation kit by CRISPRa

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SKU
GA105997
BRSK2 CRISPRa kit - CRISPR gene activation of human BR serine/threonine kinase 2
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA306412 Rabbit Polyclonal BRSK2 Antibody
100 ug
$640.00
RC223466 BRSK2 (Myc-DDK-tagged)-Human BR serine/threonine kinase 2 (BRSK2)
10 ug
$612.00

Other products for "BRSK2"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol BRSK2
Locus ID 9024
Components

GA105997G1, BRSK2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA105997G2, BRSK2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA105997G3, BRSK2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001256627, NM_001256629, NM_001256630, NM_001282218, NM_003957, NR_046331, NR_046332
UniProt ID Q8IWQ3
Synonyms C11orf7; PEN11B; SAD1; SADA; STK29
Summary Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress.UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN423466 BRSK2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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