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Human Beta TRCP (BTRC) activation kit by CRISPRa

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SKU
GA105963
BTRC CRISPRa kit - CRISPR gene activation of human beta-transducin repeat containing E3 ubiquitin protein ligase
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA502465 BTRC (Beta TRCP) mouse monoclonal antibody, clone OTI2H2 (formerly 2H2) 100 ul
$447.00
RC207025 BTRC (Myc-DDK-tagged)-Human beta-transducin repeat containing (BTRC), transcript variant 1
10 ug
$289.00 $563.00

Other products for "BTRC"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol BTRC
Locus ID 8945
Components

GA105963G1, Beta TRCP gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA105963G2, Beta TRCP gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA105963G3, Beta TRCP gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001256856, NM_003939, NM_033637
UniProt ID Q9Y297
Synonyms BETA-TRCP; betaTrCP; bTrCP; bTrCP1; FBW1A; FBXW1; FBXW1A; FWD1
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. provided by RefSeq, Mar 2012
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Documents
Resources
Other Versions
SKU Description Size Price
KN407025 BTRC - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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