Human PHOX2B activation kit by CRISPRa

SKU GA105950

PHOX2B CRISPRa kit - CRISPR gene activation of human paired like homeobox 2B

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PHOX2B
• Locus ID: 8929
• Components:

  GA105950G1, PHOX2B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105950G2, PHOX2B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105950G3, PHOX2B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_003924
• UniProt ID: Q99453
• Synonyms: NBLST2; NBPhox; PMX2B
• Summary: The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome. [provided by RefSeq, Jul 2016]