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Human SPHK1 activation kit by CRISPRa

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SKU
GA105910
SPHK1 CRISPRa kit - CRISPR gene activation of human sphingosine kinase 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA507215 SPHK1 mouse monoclonal antibody, clone OTI1A6 (formerly 1A6) 100 ul
$447.00
RC203398 SPHK1 (Myc-DDK-tagged)-Human sphingosine kinase 1 (SPHK1), transcript variant 1
10 ug
$686.00

Other products for "SPHK1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol SPHK1
Locus ID 8877
Components

GA105910G1, SPHK1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA105910G2, SPHK1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA105910G3, SPHK1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001142601, NM_001142602, NM_021972, NM_182965, NM_001355139
UniProt ID Q9NYA1
Synonyms SPHK
Summary The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Sep 2017
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Documents
Resources
Other Versions
SKU Description Size Price
KN403398 SPHK1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

file-alt Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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