Human KAT2B activation kit by CRISPRa

SKU GA105889

KAT2B CRISPRa kit - CRISPR gene activation of human lysine acetyltransferase 2B

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: KAT2B
• Locus ID: 8850
• Components:

  GA105889G1, KAT2B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105889G2, KAT2B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105889G3, KAT2B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_003884
• UniProt ID: Q92831
• Synonyms: CAF; P/CAF; PCAF
• Summary: CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008]