Human RIP (RIPK1) activation kit by CRISPRa

SKU GA105801

RIPK1 CRISPRa kit - CRISPR gene activation of human receptor interacting serine/threonine kinase 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: RIPK1
• Locus ID: 8737
• Components:

  GA105801G1, RIP gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105801G2, RIP gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105801G3, RIP gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001317061, NM_003804, NM_001354930, NM_001354931, NM_001354932, NM_001354933, NM_001354934
• UniProt ID: Q13546
• Synonyms: RIP; RIP-1; RIP1
• Summary: This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017]