Human SOCS1 activation kit by CRISPRa

SKU GA105734

SOCS1 CRISPRa kit - CRISPR gene activation of human suppressor of cytokine signaling 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: SOCS1
• Locus ID: 8651
• Components:

  GA105734G1, SOCS1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105734G2, SOCS1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105734G3, SOCS1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_003745
• UniProt ID: O15524
• Synonyms: CIS1; CISH1; JAB; SOCS-1; SSI-1; SSI1; TIP3
• Summary: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]