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Human PPM1D activation kit by CRISPRa

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SKU
GA105612
PPM1D CRISPRa kit - CRISPR gene activation of human protein phosphatase, Mg2+/Mn2+ dependent 1D
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC209328 PPM1D (Myc-DDK-tagged)-Human protein phosphatase, Mg2+/Mn2+ dependent, 1D (PPM1D)
10 ug
$844.00

Other products for "PPM1D"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol PPM1D
Locus ID 8493
Components

GA105612G1, PPM1D gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA105612G2, PPM1D gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA105612G3, PPM1D gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_003620
UniProt ID O15297
Synonyms PP2C-DELTA; WIP1
Summary The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN209328 PPM1D - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN209328BN PPM1D - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN209328LP PPM1D - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN209328RB PPM1D - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN409328 PPM1D - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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