Human LTBP4 activation kit by CRISPRa

SKU GA105563

LTBP4 CRISPRa kit - CRISPR gene activation of human latent transforming growth factor beta binding protein 4

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: LTBP4
• Locus ID: 8425
• Components:

  GA105563G1, LTBP4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105563G2, LTBP4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105563G3, LTBP4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001042544, NM_001042545, NM_003573
• UniProt ID: Q8N2S1
• Synonyms: ARCL1C; LTBP-4; LTBP4L; LTBP4S
• Summary: The protein encoded by this gene binds transforming growth factor beta (TGFB) as it is secreted and targeted to the extracellular matrix. TGFB is biologically latent after secretion and insertion into the extracellular matrix, and sheds TGFB and other proteins upon activation. Defects in this gene may be a cause of cutis laxa and severe pulmonary, gastrointestinal, and urinary abnormalities. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]