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Human ULK1 activation kit by CRISPRa

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SKU
GA105555
ULK1 CRISPRa kit - CRISPR gene activation of human unc-51 like autophagy activating kinase 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA383092 ULK1 Rabbit polyclonal Antibody
100 ul
$410.00
RC215643 ULK1 (Myc-DDK-tagged)-Human unc-51-like kinase 1 (C. elegans) (ULK1)
10 ug
$1,371.00

Other products for "ULK1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol ULK1
Locus ID 8408
Components

GA105555G1, ULK1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA105555G2, ULK1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA105555G3, ULK1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_003565
UniProt ID O75385
Synonyms ATG1; ATG1A; hATG1; UNC51; Unc51.1
Summary Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN215643 ULK1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN215643BN ULK1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN215643LP ULK1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN215643RB ULK1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN415643 ULK1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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