Human TKTL1 activation kit by CRISPRa

SKU GA105463

TKTL1 CRISPRa kit - CRISPR gene activation of human transketolase like 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: TKTL1
• Locus ID: 8277
• Components:

  GA105463G1, TKTL1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105463G2, TKTL1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105463G3, TKTL1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001145933, NM_001145934, NM_012253
• UniProt ID: P51854
• Synonyms: TKR; TKT2
• Summary: The protein encoded by this gene is a transketolase that acts as a homodimer and catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate. This reaction links the pentose phosphate pathway with the glycolytic pathway. Variations in this gene may be the cause of Wernicke-Korsakoff syndrome. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]