Human Adracalin (AAAS) activation kit by CRISPRa

SKU GA105406

AAAS CRISPRa kit - CRISPR gene activation of human aladin WD repeat nucleoporin

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: AAAS
• Locus ID: 8086
• Components:

  GA105406G1, Adracalin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105406G2, Adracalin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105406G3, Adracalin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001173466, NM_015665
• UniProt ID: Q9NRG9
• Synonyms: AAA; AAASb; ADRACALA; ADRACALIN; ALADIN; GL003
• Summary: The protein encoded by this gene is a member of the WD-repeat family of regulatory proteins and may be involved in normal development of the peripheral and central nervous system. The encoded protein is part of the nuclear pore complex and is anchored there by NDC1. Defects in this gene are a cause of achalasia-addisonianism-alacrima syndrome (AAAS), also called triple-A syndrome or Allgrove syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]