Human UBE2H activation kit by CRISPRa

SKU GA105048

UBE2H CRISPRa kit - CRISPR gene activation of human ubiquitin conjugating enzyme E2 H

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: UBE2H
• Locus ID: 7328
• Components:

  GA105048G1, UBE2H gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105048G2, UBE2H gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105048G3, UBE2H gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001202498, NM_003344, NM_182697
• UniProt ID: P62256
• Synonyms: E2-20K; GID3; UBC8; UBCH; UBCH2
• Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]