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Human DAP12 (TYROBP) activation kit by CRISPRa

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SKU
GA105031
TYROBP CRISPRa kit - CRISPR gene activation of human TYRO protein tyrosine kinase binding protein
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC222502 TYROBP (Myc-DDK-tagged)-Human TYRO protein tyrosine kinase binding protein (TYROBP), transcript variant 1
10 ug
$225.00

Other products for "TYROBP"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol TYROBP
Locus ID 7305
Components

GA105031G1, DAP12 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA105031G2, DAP12 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA105031G3, DAP12 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001173514, NM_001173515, NM_003332, NM_198125, NR_033390
UniProt ID O43914
Synonyms DAP12; KARAP; PLOSL
Summary This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. provided by RefSeq, Mar 2010
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Documents
Resources
Other Versions
SKU Description Size Price
KN403771 TYROBP - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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