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Human TNNT3 activation kit by CRISPRa

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SKU
GA104932
TNNT3 CRISPRa kit - CRISPR gene activation of human troponin T3, fast skeletal type
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA339175 Rabbit Polyclonal Anti-TNNT3
100 ul
$585.00
RC212563 TNNT3 (Myc-DDK-tagged)-Human troponin T type 3 (skeletal, fast) (TNNT3), transcript variant 3
10 ug
$300.00

Other products for "TNNT3"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol TNNT3
Locus ID 7140
Components

GA104932G1, TNNT3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA104932G2, TNNT3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA104932G3, TNNT3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001042780, NM_001042781, NM_001042782, NM_001297646, NM_006757, NM_001367842, NM_001367843, NM_001367844, NM_001367846, NM_001363561, NM_001367845, NM_001367847, NM_001367848, NM_001367849, NM_001367850, NM_001367851, NM_001367852
UniProt ID P45378
Synonyms TNTF
Summary The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). provided by RefSeq, Oct 2009
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Documents
Resources
Other Versions
SKU Description Size Price
KN412563 TNNT3 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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