Human Thymidine Kinase 2 (TK2) activation kit by CRISPRa

SKU GA104886

TK2 CRISPRa kit - CRISPR gene activation of human thymidine kinase 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: TK2
• Locus ID: 7084
• Components:

  GA104886G1, Thymidine Kinase 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104886G2, Thymidine Kinase 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104886G3, Thymidine Kinase 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001172643, NM_001172644, NM_001172645, NM_001271934, NM_001271935, NM_001272050, NM_004614, NR_073520, NR_073521
• UniProt ID: O00142
• Synonyms: MTDPS2; MTTK; SCA31
• Summary: This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012]