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Human TIAM1 activation kit by CRISPRa

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SKU
GA104877
TIAM1 CRISPRa kit - CRISPR gene activation of human T cell lymphoma invasion and metastasis 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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100 ul
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RC220233 TIAM1 (Myc-DDK-tagged)-Human T-cell lymphoma invasion and metastasis 1 (TIAM1)
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Other products for "TIAM1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol TIAM1
Locus ID 7074
Components

GA104877G1, TIAM1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA104877G2, TIAM1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA104877G3, TIAM1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_003253, NM_001353684, NM_001353685, NM_001353686, NM_001353687, NM_001353688, NM_001353689, NM_001353690, NM_001353691, NM_001353692, NM_001353693, NM_001353694
UniProt ID Q13009
Synonyms FLJ36302
Summary This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain. provided by RefSeq, Jul 2017
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Documents
Resources
Other Versions
SKU Description Size Price
KN420233 TIAM1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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