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Human Thyroid Hormone Receptor beta (THRB) activation kit by CRISPRa

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SKU
GA104871
THRB CRISPRa kit - CRISPR gene activation of human thyroid hormone receptor beta
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA311778 Rabbit polyclonal Thyroid Hormone Receptor Beta antibody
100 ul
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RC217873 THRB (Myc-DDK-tagged)-Human thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) (THRB), transcript variant 1
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Other products for "THRB"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol THRB
Locus ID 7068
Components

GA104871G1, Thyroid Hormone Receptor beta gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA104871G2, Thyroid Hormone Receptor beta gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA104871G3, Thyroid Hormone Receptor beta gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_000461, NM_001128176, NM_001128177, NM_001252634, NM_001354708, NM_001354709, NM_001354710, NM_001354711, NM_001354712, NM_001354713, NM_001354714, NM_001354715
UniProt ID P10828
Synonyms C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2; PRTH; THR1; THRB1; THRB2
Summary The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN417873 THRB - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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