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Human SUR1 (ABCC8) activation kit by CRISPRa

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SKU
GA104701
ABCC8 CRISPRa kit - CRISPR gene activation of human ATP binding cassette subfamily C member 8
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA351769 Rabbit Polyclonal Anti-ABCC8 Antibody
100 ul
$205.00
RC215352 ABCC8 (Myc-DDK-tagged)-Human ATP-binding cassette, sub-family C (CFTR/MRP), member 8 (ABCC8)
10 ug
$589.00 $1,352.00

Other products for "ABCC8"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol ABCC8
Locus ID 6833
Components

GA104701G1, SUR1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA104701G2, SUR1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA104701G3, SUR1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_000352, NM_001287174, NM_001351295, NM_001351296, NM_001351297, NR_147094
UniProt ID Q09428
Synonyms ABC36; HHF1; HI; HRINS; MRP8; PHHI; SUR; SUR1; SUR1delta2; TNDM2
Summary The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations in the ABCC8 gene and deficiencies in the encoded protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. provided by RefSeq, Jul 2020
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Resources
Other Versions
SKU Description Size Price
KN415352 ABCC8 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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