Human Slap (SLA) activation kit by CRISPRa

SKU GA104428

SLA CRISPRa kit - CRISPR gene activation of human Src like adaptor

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: SLA
• Locus ID: 6503
• Components:

  GA104428G1, Slap gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104428G2, Slap gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104428G3, Slap gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001045556, NM_001045557, NM_001282964, NM_001282965, NM_006748
• UniProt ID: Q13239
• Synonyms: SLA1; SLAP
• Summary: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.[UniProtKB/Swiss-Prot Function]