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Human STIL activation kit by CRISPRa

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SKU
GA104417
STIL CRISPRa kit - CRISPR gene activation of human STIL centriolar assembly protein
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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RC220810 STIL (Myc-DDK-tagged)-Human SCL/TAL1 interrupting locus (STIL), transcript variant 2
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Other products for "STIL"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol STIL
Locus ID 6491
Components

GA104417G1, STIL gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA104417G2, STIL gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA104417G3, STIL gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001048166, NM_001282936, NM_001282937, NM_001282938, NM_001282939, NM_003035
UniProt ID Q15468
Synonyms MCPH7; SIL
Summary This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN420810 STIL - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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