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Human RPE65 activation kit by CRISPRa

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SKU
GA104142
RPE65 CRISPRa kit - CRISPR gene activation of human retinoid isomerohydrolase RPE65
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC210433 RPE65 (Myc-DDK-tagged)-Human retinal pigment epithelium-specific protein 65kDa (RPE65)
10 ug
$744.00

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Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol RPE65
Locus ID 6121
Components

GA104142G1, RPE65 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA104142G2, RPE65 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA104142G3, RPE65 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_000329
UniProt ID Q16518
Synonyms BCO3; LCA2; mRPE65; rd12; RP20; sRPE65
Summary The protein encoded by this gene is a component of the vitamin A visual cycle of the retina which supplies the 11-cis retinal chromophore of the photoreceptors opsin visual pigments. It is a member of the carotenoid cleavage oxygenase superfamily. All members of this superfamily are non-heme iron oxygenases with a seven-bladed propeller fold and oxidatively cleave carotenoid carbon:carbon double bonds. However, the protein encoded by this gene has acquired a divergent function that involves the concerted O-alkyl ester cleavage of its all-trans retinyl ester substrate and all-trans to 11-cis double bond isomerization of the retinyl moiety. As such, it performs the essential enzymatic isomerization step in the synthesis of 11-cis retinal. Mutations in this gene are associated with early-onset severe blinding disorders such as Leber congenital. provided by RefSeq, Oct 2017
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Documents
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Other Versions
SKU Description Size Price
KN410433 RPE65 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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