Human ROR alpha (RORA) activation kit by CRISPRa

SKU GA104130

RORA CRISPRa kit - CRISPR gene activation of human RAR related orphan receptor A

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: RORA
• Locus ID: 6095
• Components:

  GA104130G1, ROR alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104130G2, ROR alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104130G3, ROR alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_002943, NM_134260, NM_134261, NM_134262
• UniProt ID: P35398
• Synonyms: NR1F1; ROR1; ROR2; ROR3; RZR-ALPHA; RZRA
• Summary: The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]