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Human RAP1GAP activation kit by CRISPRa

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SKU
GA104019
RAP1GAP CRISPRa kit - CRISPR gene activation of human RAP1 GTPase activating protein
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA385130 RAP1GAP Rabbit monoclonal Antibody
100 ul
$380.00
RC208271 RAP1GAP (Myc-DDK-tagged)-Human RAP1 GTPase activating protein (RAP1GAP), transcript variant 3
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Other products for "RAP1GAP"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol RAP1GAP
Locus ID 5909
Components

GA104019G1, RAP1GAP gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA104019G2, RAP1GAP gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA104019G3, RAP1GAP gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001145657, NM_001145658, NM_001330383, NM_002885, NM_001350524, NM_001350525, NM_001350526, NM_001350527, NM_001350528
UniProt ID P47736
Synonyms RAP1GA1; RAP1GAP1; RAP1GAPII; RAPGAP
Summary This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. provided by RefSeq, Aug 2011
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Documents
Resources
Other Versions
SKU Description Size Price
KN408271 RAP1GAP - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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