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Human RAN activation kit by CRISPRa

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SKU
GA104013
RAN CRISPRa kit - CRISPR gene activation of human RAN, member RAS oncogene family
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA350325 Rabbit Polyclonal Anti-RAN Antibody
100 ul
$205.00
RC208738 RAN (Myc-DDK-tagged)-Human RAN, member RAS oncogene family (RAN)
10 ug
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Other products for "RAN"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol RAN
Locus ID 5901
Components

GA104013G1, RAN gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA104013G2, RAN gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA104013G3, RAN gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001300796, NM_001300797, NM_006325
UniProt ID P62826
Synonyms ARA24; Gsp1; TC4
Summary RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN408738 RAN - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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