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Human RAD17 activation kit by CRISPRa

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SKU
GA103997
RAD17 CRISPRa kit - CRISPR gene activation of human RAD17 checkpoint clamp loader component
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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20 ug
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RC215866 RAD17 (Myc-DDK-tagged)-Human RAD17 homolog (S. pombe) (RAD17), transcript variant 5
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Other products for "RAD17"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol RAD17
Locus ID 5884
Components

GA103997G1, RAD17 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA103997G2, RAD17 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA103997G3, RAD17 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001278622, NM_002873, NM_133338, NM_133339, NM_133340, NM_133341, NM_133342, NM_133343, NM_133344
UniProt ID O75943
Synonyms CCYC; HRAD17; R24L; RAD17SP; RAD24
Summary The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. provided by RefSeq, Jul 2013
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Other Versions
SKU Description Size Price
KN407114 RAD17 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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