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Human PRCP activation kit by CRISPRa

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SKU
GA103744
PRCP CRISPRa kit - CRISPR gene activation of human prolylcarboxypeptidase
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC200677 PRCP (Myc-DDK-tagged)-Human prolylcarboxypeptidase (angiotensinase C) (PRCP), transcript variant 1
10 ug
$457.00

Other products for "PRCP"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol PRCP
Locus ID 5547
Components

GA103744G1, PRCP gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA103744G2, PRCP gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA103744G3, PRCP gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001319214, NM_005040, NM_199418
UniProt ID P42785
Synonyms HUMPCP; PCP
Summary This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. provided by RefSeq, Jan 2016
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Other Versions
SKU Description Size Price
KN400677 PRCP - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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