Human PPP2R1B activation kit by CRISPRa

SKU GA103718

PPP2R1B CRISPRa kit - CRISPR gene activation of human protein phosphatase 2 scaffold subunit Abeta

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PPP2R1B
• Locus ID: 5519
• Components:

  GA103718G1, PPP2R1B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103718G2, PPP2R1B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103718G3, PPP2R1B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001177562, NM_001177563, NM_002716, NM_181699, NM_181700
• UniProt ID: P30154
• Synonyms: PP2A-Abeta; PR65B
• Summary: This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]