Human Cyclophilin A (PPIA) activation kit by CRISPRa

SKU GA103695

PPIA CRISPRa kit - CRISPR gene activation of human peptidylprolyl isomerase A

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PPIA
• Locus ID: 5478
• Components:

  GA103695G1, Cyclophilin A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103695G2, Cyclophilin A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103695G3, Cyclophilin A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001300981, NM_021130, NM_203430, NM_203431
• UniProt ID: P62937
• Synonyms: CYPA; CYPH; HEL-S-69p
• Summary: This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]