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Human ACTH (POMC) activation kit by CRISPRa

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SKU
GA103666
POMC CRISPRa kit - CRISPR gene activation of human proopiomelanocortin
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA506610 POMC mouse monoclonal antibody, clone OTI2B2 (formerly 2B2) 100 ul
$447.00
RC215351 POMC (Myc-DDK-tagged)-Human proopiomelanocortin (POMC), transcript variant 1
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Other products for "POMC"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol POMC
Locus ID 5443
Components

GA103666G1, ACTH gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA103666G2, ACTH gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA103666G3, ACTH gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_000939, NM_001035256, NM_001319204, NM_001319205
UniProt ID P01189
Synonyms ACTH; CLIP; LPH; MSH; NPP; POC
Summary This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. provided by RefSeq, Jan 2016
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Documents
Resources
Other Versions
SKU Description Size Price
KN409619 POMC - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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