Human SEPTIN4 activation kit by CRISPRa

SKU GA103643

SEPTIN4 CRISPRa kit - CRISPR gene activation of human septin 4

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: SEPTIN4
• Locus ID: 5414
• Components:

  GA103643G1, SEPTIN4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103643G2, SEPTIN4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103643G3, SEPTIN4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001038704, NM_001198713, NM_001256782, NM_001256822, NM_004574, NM_080415, NM_080416, NM_080417, NR_037155, NR_037156, NR_104196, NR_104197, NM_001363803, NM_001368771, NM_001368772
• UniProt ID: O43236
• Synonyms: ARTS; BRADEION; CE5B3; H5; hCDCREL-2; hucep-7; MART; PNUTL2; SEP4
• Summary: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010]