Human PLA2G1B activation kit by CRISPRa

SKU GA103580

PLA2G1B CRISPRa kit - CRISPR gene activation of human phospholipase A2 group IB

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PLA2G1B
• Locus ID: 5319
• Components:

  GA103580G1, PLA2G1B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103580G2, PLA2G1B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103580G3, PLA2G1B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000928
• UniProt ID: P04054
• Synonyms: PLA2; PLA2A; PPLA2
• Summary: This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]