Human PKHD1 activation kit by CRISPRa

SKU GA103575

PKHD1 CRISPRa kit - CRISPR gene activation of human PKHD1 ciliary IPT domain containing fibrocystin/polyductin

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PKHD1
• Locus ID: 5314
• Components:

  GA103575G1, PKHD1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103575G2, PKHD1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103575G3, PKHD1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_138694, NM_170724
• UniProt ID: P08F94
• Synonyms: ARPKD; FCYT; TIGM1
• Summary: The protein encoded by this gene is predicted to have a single transmembrane (TM)-spanning domain and multiple copies of an immunoglobulin-like plexin-transcription-factor domain. Alternative splicing results in two transcript variants encoding different isoforms. Other alternatively spliced transcripts have been described, but the full length sequences have not been determined. Several of these transcripts are predicted to encode truncated products which lack the TM and may be secreted. Mutations in this gene cause autosomal recessive polycystic kidney disease, also known as polycystic kidney and hepatic disease-1. [provided by RefSeq, Jul 2008]