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Human PC1/3 (PCSK1) activation kit by CRISPRa

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SKU
GA103423
PCSK1 CRISPRa kit - CRISPR gene activation of human proprotein convertase subtilisin/kexin type 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA334299 Rabbit Polyclonal Anti-PCSK1 Antibody
100 ul
$585.00
RC221711 PCSK1 (Myc-DDK-tagged)-Human proprotein convertase subtilisin/kexin type 1 (PCSK1), transcript variant 1
10 ug
$1,034.00

Other products for "PCSK1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol PCSK1
Locus ID 5122
Components

GA103423G1, PC1/3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA103423G2, PC1/3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA103423G3, PC1/3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_000439, NM_001177875, NM_001177876
UniProt ID P29120
Synonyms BMIQ12; NEC1; PC1; PC3; SPC3
Summary This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene provided by RefSeq, Jan 2014
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Documents
Resources
Other Versions
SKU Description Size Price
KN221711 PCSK1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN221711BN PCSK1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN221711LP PCSK1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN221711RB PCSK1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN421711 PCSK1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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