Human ORC4L (ORC4) activation kit by CRISPRa

SKU GA103334

ORC4 CRISPRa kit - CRISPR gene activation of human origin recognition complex subunit 4

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: ORC4
• Locus ID: 5000
• Components:

  GA103334G1, ORC4L gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103334G2, ORC4L gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103334G3, ORC4L gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001190879, NM_001190881, NM_001190882, NM_002552, NM_181741, NM_181742
• UniProt ID: O43929
• Synonyms: ORC4L; ORC4P
• Summary: The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene. [provided by RefSeq, Oct 2010]