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Human OAZ2 activation kit by CRISPRa

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SKU
GA103304
OAZ2 CRISPRa kit - CRISPR gene activation of human ornithine decarboxylase antizyme 2
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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100 ul
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RC215120 OAZ2 (Myc-DDK-tagged)-Human ornithine decarboxylase antizyme 2 (OAZ2)
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Other products for "OAZ2"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol OAZ2
Locus ID 4947
Components

GA103304G1, OAZ2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA103304G2, OAZ2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA103304G3, OAZ2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001301302, NM_002537
UniProt ID O95190
Summary The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamines. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. provided by RefSeq, Dec 2014
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Documents
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Other Versions
SKU Description Size Price
KN415120 OAZ2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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